Second Generation of Calcium Antagonists Info

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"Another damned, thick, square book! Always scribble, scribble,
scribble! Eh! Mr. Gibbon?" From the Literary Memoirs of Willi­ am, DUKE
OF GLOUCESTER, 1743-1805 The foreword of any book is probably the most
difficult to write -not only because it stands at the beginning of an
exercise in writing and logic but because it is in this chapter that
areader can expect to find a clear and unambiguous explanation of the
author's reason for writing the book and why some subject matter has
been included and other subject matter excluded. Potential readers
ofthis book may not have an inclination to question why some subject
matter has been excluded but instead may wonder why another book on
calcium antagonists has been published. However, it is arguable with
some force that there have been at least three recent developments in
the field of calcium antagonism which provide more than adequate support
for the view that another book on this topic is warranted. These
developments include: (i) an improved understanding of the chemical
structure, mode of action and architecture of the voltage-activated,
calcium antagonist-sensitive calcium channels and their associated
calcium-antagonist specific binding sites; (ii) a more accurate
appreciation ofhow and when the calcium antagonists should be used in
the management of a variety of clinical dis orders including cerebral
ischaemia atherosclerosis, "mild" ischaemic heart disease, ventricular
hyper­ trophy, impaired ventricular relaxation and hypertension (to name
but a few), and (iii) the emergence of a second generation of calcium

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